If you are coming to Panama on business and need a hotel right dab in the center of the financial center, then  you might want to consider Hotel Riu on Calle 50.  Most banks and many important businesses are within walking distance.  The hotel is spacious and modern.  I have never stayed there, but I have eaten in the restaurant and the coffee shop.  The coffee shop gets five stars from me. However, I wasn’t too impressed with the restaurant and its service.  Below is a picture of the hotel lobby.